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J Neuropsychiatry Clin Neurosci 1992; 4:134-139
Copyright © 1992 by American Neuropsychiatric Association
Reliability, validity, and clinical correlates of apathy in Parkinson's disease
SE Starkstein, HS Mayberg, TJ Preziosi, P Andrezejewski, R Leiguarda and RG Robinson
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland.
The authors examined a consecutive series of 50 patients for the presence
of apathy, depression, anxiety, and neuropsychological deficits using a
neuropsychological battery that included a recently designed apathy scale.
This scale was found to be reliable and valid in the diagnosis of apathy in
patients with PD. Of patients in the study, 12% showed apathy as their
primary psychiatric problem, and 30% were both apathetic and depressed.
Patients with apathy (with or without depression), showed significantly
more deficits in both tasks of verbal memory and time-dependent tasks.
Results suggest that apathy is a frequent finding in PD, is significantly
associated with specific cognitive impairments, and may have a different
mechanism than depression.
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