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Late-Life Reactivation of Obsessive-Compulsive Disorder Associated With Lesions in Prefrontal-Subcortical Circuits

Received March 3, 2008; revised June 24 and July 10, 2008; accepted July 16, 2008. Ms. Salinas is affiliated with the Florida Institute of Technology in Melbourne, Fl.; Dr. Dávila is affiliated with the Departamento de Psicobiología, Facultad de Psicología, Universidad de Málaga, Spain; Drs. Berthier, Green, and Lara are affiliated with the Unidad de Neurología Cognitiva y Afasia, y Unidad de Neurofisiología Humana. Address correspondence to Dr. Marcelo L. Berthier. Unidad de Neurología Cognitiva y Afasia, Centro de Investigaciones Médico-Sanitarias (CIMES), Universidad de Málaga, Marqués de Beccaria 3, Campus Universitario Teatinos 29010, Málaga, España; marberthier{at}yahoo.es (e-mail).

ABSTRACT

The authors describe the reactivation of obsessive-compulsive disorder (OCD) in three patients with lesions in the prefronto-subcortical circuits after decades of being asymptomatic. The patients also reported the emergence of new OCD symptoms and motor/phonic tics as well as mental rituals thematically related to the negative experience of suffering cognitive and motor deficits.

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