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Disinhibition Due to Disruption of the Orbitofrontal Circuit Treated Successfully With Carbamazepine: A Case Series

Received December 24, 2007; revised March 27 and July 17, 2008; accepted July 21, 2008. The authors are affiliated with EVMS Psychiatry in Norfolk, VA. Address correspondence to Dr. David R. Spiegel, Eastern Virginia Medical School, Department of Psychiatry and Behavioral Sciences, 825 Fairfax Ave., Norfolk, VA 23507; SpiegeDR{at}evms.edu (e-mail).

ABSTRACT

The frontal-subcortical pathways play a role in governing behavior. Injury may disrupt their functioning and produce neuropsychiatric symptoms. The authors discuss the kindling theory in the possible production of these symptoms, which significantly improved with the potent antikindling agent, carbamazepine.

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