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Evaluating the Affective Component of the Cerebellar Cognitive Affective Syndrome

Received May 12, 2008; revised August 18 and November 7, 2008; accepted November 13, 2008. Dr. Wolf is affiliated with the Department of Psychiatry at the University of Toronto in Toronto, Canada; Dr. Rapoport is affiliated with the Department of Psychiatry at Sunnybrook Health Sciences Centre, University of Toronto, in Toronto; Dr. Schweizer is affiliated with the Department of Surgery, Division of Neurosurgery, at the University of Toronto and the Kennan Research Centre of the Li Ka Shing Knowledge Institute at St. Michael’s Hospital in Toronto. Address correspondence to Tom A. Schweizer, Ph.D., St. Michael’s Hospital, Department of Neurosurgery, 30 Bond St., M5B 1W8, Toronto, Canada; schweizert{at}smh.toronto.on.ca (e-mail).

The authors performed a systematic review and meta-analysis of studies evaluating the affective component of the cerebellar cognitive affective syndrome. Depressive and anxiety symptoms and personality changes were more frequent in patients with spinocerebellar ataxia. Patients with cerebellar lesions were more likely to have depression, deficits in the ability to experience emotions, and behavioral difficulties. A meta-analysis revealed modestly higher scores on the Hamilton Depression Rating Scale (HAM-D) among patients with cerebellar disease. This review highlights the need for cohort studies using noncerebellar comparison groups, more sensitive measures, and appropriate-sized populations with isolated cerebellar lesions to thoroughly assess the affective component of the cerebellar cognitive affective syndrome.

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